From this medical article you can get acquainted with the drug Vemox 500 (Amoxicillin). Instructions for use will explain in which cases you can take the medicine, from what it helps, what are the indications for use, contraindications and side effects. The annotation contains the form of the preparation and its composition.
In the article, doctors and consumers can leave only real reviews about Amoxicillin, from which one can find out whether the medicine helped in the therapy of pneumonia, bronchitis, pyelonephritis and other infectious pathologies in children and adults. The instructions list analogues of Vemox 500, drug prices in pharmacies, as well as its use in pregnancy.
Form of issue and composition
Amoxicillin is produced in the following forms:
- tablets of 250 mg and 500 mg;
- capsules of 250 mg and 500 mg each;
- Granules for the preparation of suspension (syrup) 250 mg is a children’s release form.
The capsules contain the active ingredient amoxicillin (in the composition of the drug as a trihydrate). A similar active substance is present in the composition of the tablets, as well as the granules from which the suspension is prepared.
Vemox 500: Pharmacological properties
Amoxicillin is an antibacterial bactericidal acid-resistant broad spectrum agent from the group of semisynthetic penicillins. It inhibits transpeptidase, breaks the synthesis of peptidoglycan (the supporting protein of the cell wall) in the period of division and growth, causes bacterial lysis.
It is active against aerobic gram-positive and aerobic gram-negative bacteria. The microorganisms producing penicillinase are resistant to the action of amoxicillin.
The effect of Amoxicillin begins in half an hour after taking and lasts for 6-8 hours, so to maintain a constant concentration of the drug in the body, it is prescribed three times a day. The drug is effective against most pathogens, except for strains producing penicillinase.
What helps Vemox 500
Indications for use include the treatment of bacterial infections caused by sensitive microflora:
- Lyme disease (borreliosis);
- endocarditis (prophylaxis);
- infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses); leptospirosis;
- respiratory tract infections and ENT organs (sinusitis, pharyngitis, tonsillitis, acute otitis media, bronchitis, pneumonia);
- infection of the genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis);
- infections of the digestive tract (peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis).
Instructions for use
Amoxicillin should be taken orally by washing with water. You can take an antibiotic regardless of the meal.
For adults and children who are already 12 years of age, usually prescribed 500 mg of amoxicillin three times a day. However, the dosage depends on the disease and the doctor’s appointment in each case. In severe cases, the dose can be increased to 750-1000 mg, the maximum allowable dose per day is 6 g.
High doses of the drug are prescribed for typhoid fever (1.5-2 g three times a day), with leptospirosis (500-750 mg four times a day). Tablets or capsules must be taken two or three more days after the disappearance of signs of the disease. In most cases, treatment lasts from 5 to 12 days.
Side effect of Vemox 500
According to the instructions, the drug Vemox 500 can cause such negative reactions as:
- confusion of consciousness;
- superinfection (especially in patients with chronic diseases or reduced resistance of the body);
- pain in the joints;
- vomiting, nausea;
- behavior change;
- Stevens-Johnson syndrome;
- leukopenia, neutropenia;
- anaphylactic shock;
- headache, dizziness;
- hyperemia of the skin;
- stomatitis, glossitis.
Vemox 500: Contraindications
Do not use the medicine if the patient has:
- bronchial asthma;
- allergic diathesis;
- liver failure;
- hypersensitivity (including to other penicillins, cephalosporins, carbapenems) and the composition of the drug Vemox 500, from which syrup and tablets can cause adverse reactions;
- lymphocytic leukemia;
- lactation period;
- Gastrointestinal disease in history (especially colitis, associated with the use of antibiotics);
- Infectious mononucleosis.
In pregnancy and lactation
It should be borne in mind that the substance amoxicillin is able to penetrate the placental barrier. But still during pregnancy, according to the indications, this remedy is prescribed for women with inflammatory diseases. It is prescribed for bacterial infections.
The drug can provoke the development of dysbacteriosis, allergic reactions, activation of fungal microflora. Reviews about Vemox 500 during pregnancy are mainly indicative of its effectiveness and a rare manifestation of side effects.
When lactation, the drug should not be taken, as it enters the breast milk. If treatment of inflammatory processes is required for lactation, another drug is prescribed or natural feeding is stopped.
Interaction Vemox 500 with other drugs
Increases the absorption of digoxin. Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index). Monitoring prothrombin time should be carried out with simultaneous appointment with anticoagulants.
Reduces the effectiveness of estrogen-containing oral contraceptives, drugs, in the process of metabolism of which forms para-aminobenzoic acid, ethinyl estradiol – the risk of bleeding “breakthrough”. Reduces clearance and increases the toxicity of methotrexate.
Antibacterial activity decreases with simultaneous use with bacteriostatic chemotherapeutic agents, increases – when combined with aminoglycosides and metronidazole. There is complete cross-resistance of ampicillin and amoxicillin.
Antacids, glucosamine, laxatives slow down and reduce, and ascorbic acid increases absorption. Excretion is slowed by probenecid, allopurinol, sulfinpyrazone, acetylsalicylic acid, indomethacin, oxyphenbutazone, phenylbutazone and other drugs that inhibit tubular secretion.
Vemox 500: Special conditions
Patients with gonorrhea need to carry out serological tests for syphilis at the time of diagnosis. In patients receiving amoxicillin, subsequent serological control for syphilis should be performed after 3 months. Use with caution in patients prone to allergic reactions.
In the process of prolonged therapy, it is necessary to monitor the function of the organs of hematopoiesis, liver and kidneys. It is possible to develop superinfection due to the growth of insensitive microflora, which requires a corresponding change in antibacterial therapy. With the appointment of patients with sepsis, it is rarely possible to develop a bacteriolysis reaction.