Magnum Anastrol refers to a new generation of highly selective aromatase inhibitors. Refers to preparations of the antitumour spectrum. It is an inhibitor of estrogens. The drug is designed to treat cancer malignant diseases of the breast.
What form of release is offered in pharmacies
On sale, Magnum Anastrol is offered in soft packs, in which there are 2 blisters. In each blister there are 14 biconvex round tablets, which are covered with a film membrane. Each tablet is engraved. On the one hand, the engraving “A”, on the other hand, the engraving “Adx / 1”.
Structure of the preparation
The active substance of this medicine is anastrozole. The tablet contains 1 mg of the active ingredient. It also includes:
- Magnesium sterate – 1 mg
- Povidone – 2 mg
- Lactose monohydrate – 93 mg
- Carboxymethylene starch sodium – 3 mg.
The composition of the film sheath used includes:
- Macrogol 300
- Titanium dioxide
What distinguishes the pharmacological action of Magnum Anastrol
The active substance of the drug has a positive effect on the malignant tumor. Especially it is distinguished by high antitumor activity, related to estrogen-dependent breast tumors, affecting women during the postmenopause.
Important: the growth of tumors during the postmenopause provokes estradiol. Magnum Anastrol is designed for selective inhibition of aromatase, which helps to reduce the level of circulating estradiol.
The decrease in the level of estradiol has a therapeutic effect for women with diagnosed breast cancer. In a dose of 1 mg, the active drug is ready to reduce the level of estradiol by 80%.
Peculiarities of pharmacokinetics of the preparation
There is no androgenic, progestagenic, estrogenic activity in Magnum Anastrol.
A special feature of the drug is the lack of the provision in the standard daily dose of 10 mg of the effect on the secretion of aldosterone and cortisol. This makes it possible to refuse when receiving a therapeutic dose from the administration of corticosteroid substitution type.
It is taken on an empty stomach, absorbed through the digestive tract. Two hours after taking the maximum dose of plasma. It is deduced for 40-50 hours. Mainly excreted in the urine. Pharmacokinetics do not depend on the age of a postmenopausal woman.
Indication of the Magnum Anastrol
The diagnoses that are the basis for prescribing the drug include:
- Early stages of malignant lesions in the mammary gland at the stage of tumor overexpression. Including after surgery
- Metastatic or locally recurrent breast cancer in women
- Neoplasms in the mammary gland of malignant type
Dosage Magnum Anastrol and other rules of admission
From the first stages of admission to adults, 1 mg of arimidex is prescribed once a day with mandatory oral administration. There is no need for additional dosage adjustment for patients suffering from concomitant diagnoses, such as severe renal and hepatic impairment.
Studies have not shown toxicity of the drug and have shown that there is no possibility of an overdose. In clinical trials, up to 60 mg of the drug was taken per day with a single dose and up to 10 mg with a daily appointment. Some cases of a trough for overdose with the appearance of nausea, which do not require special treatment, are noted.
Variants of drug interaction
The tests showed the absence of drug interaction with other drugs, including other antitumour agents. It is not recommended simultaneous administration of medications containing estrogens, as this neutralizes the effect of the drug.
While conducting studies on animals during pregnancy and lactation, there were no contraindications to admission. The practice of using amidex in women during pregnancy and lactation is not described. This becomes the basis for taking amyrodex only after consulting with the treating therapist.
Analogues of Magnum Anastrol
A wide selection of analogues of this preparation is on sale. Including:
- Selective nonsteroidal aromatase inhibitor AXASTROL
- Selective non-steroid aromatase inhibitor Anamasten
- Selective nonsteroidal aromatase inhibitor Anabrez
- Highly selective nonsteroidal aromatase inhibitor Mammozol with the ability to convert estrone to peripheral tissues of women and others.
Possible side effects of admission
When receiving, there can be observed such side effects as:
- A rush of blood to the face, showing the problem of the vascular system
- Bone tissue becomes prone to joint stiffness / arthralgia
- Appearance of nausea and vomiting
- Dryness of the dermal sheath of the vagina
- The appearance of skin rash
- Decreased bone mineral density, which increases the risk of fracture
- Medium and light asthenia, other
Storage conditions and timing of admission
Magnum Anastrol is successfully stored up to 5 years at a temperature not exceeding +30 degrees Celsius. It is released in pharmacies according to the prescription.