Aldactone 100 mg is one of the most effective pharmaceutical agents that can cope with the problem of increased blood pressure and swelling.
The drug provides potassium and magnesium-saving effects by increasing the excretion of renal tubules of water and sodium.
The diuretic effect of taking the drug is usually seen already on the second day.
In rare cases, a therapeutic effect is to be expected within 5 days.
Instructions for use Aldactone 100 mg
Due to the ability to exert a strong effect on the body and high absorption (about 90%), Aldactone belongs to the category of prescription diuretic and hypotensive drugs , which can be taken only if there is evidence.
The reason for prescribing the drug is most often the swelling that appears on the background:
- heart diseases;
- nephrotic syndrome;
- pregnancy (second and third trimesters);
- cirrhosis of the liver;
- premenstrual syndrome and polycystic ovary.
The drug can be prescribed in the treatment of hypertension, the prevention of hypercalemia, adrenal adrenal gland (if surgical treatment is impossible or the patient refuses to perform the operation).
Mode of application Aldactone 100 mg
The drug released in the form of tablets is taken internally in a dosage prescribed by the attending physician . At the same time, the patient’s state of health, the presence of chronic diseases and the individual tolerance of the active substance of the drug, spironolactone, must be taken into account.
If there are edemas on the background of other diseases – from 100 to 200 mg of the drug during the day, which should be taken in 3 doses.
In complicated cases, an increase in the daily dose up to 300 mg is possible, with the division of this amount into 3 doses.
To reduce blood pressure during arterial hypertension per day, the patient is prescribed from 50 to 100 mg of the drug. It is recommended to take Aldactone 100mg in 3 doses. With good tolerability of the drug and the presence of indications after 2 weeks of taking the medication, the daily dose can be increased to 200 mg.
In order to treat and prevent hypokalemia, the patient is prescribed from 25 to 100 mg of the drug, which can be taken once a day.
Form of issue, composition
The drug is available in the form of rounded tablets with a dosage of the main active substance – spironolactone , 25, 50 or 100 mg. In one blister can be 10 or 20 tablets.
Auxiliary components in Aldactone 100mg are: lactose, corn starch, stearic acid.
Interaction Aldactone 100mg with other drugs
The most common negative effect of taking Aldactone together with other drugs is hypokalemia. The development of the disease can trigger the intake of a diuretic and potassium-containing drugs (including vitamin complexes and salt substitutes ), ACE inhibitors, lazartone, eprosartan and candesartan.
With the simultaneous administration of Aldactone 100mg with other antihypertensive drugs , their effect is mutually reinforced.
If the drug is taken simultaneously with anticoagulants and salicylates , the diuretic effect for the body is reduced.
Reception of the drug enhances the effect of tryptorelin, buserelin, gonadorelin .
The simultaneous administration of Aldactone and digitoxin is capable of both increasing and decreasing the efficacy of the latter, as well as provoking an increase in the concentration of digoxin in the blood.
Simultaneous reception with lithium carbonate promotes an increase in the concentration of lithium in the blood.
Side effects of Aldactone 100mg
Reactions of the digestive system: intestinal disorders (constipation, diarrhea, flatulence), nausea and vomiting, abdominal pain, gastritis, the appearance of ulcers and bleeding in the stomach or intestines.
Reactions from the nervous system: retardation, drowsiness, dizziness, lethargy.
Metabolic disorders: increased urea concentration, metabolic acidosis or alkalosis, disruptions in water-salt metabolism.
Problems with blood formation: megaloblasticosis, agranulocytosis, thrombocytopenia.
Development of allergic reactions: itching, fever, skin rashes in the form of urticaria, eczema, etc.
Disorders of the endocrine system (in the case of long-term drug intake): in men – gynecomastia and erectile dysfunction, in women – menstrual irregularities, bleeding during menopause, pain in the mammary glands, breast carcinoma, voice change. In rare cases, there may be muscle spasms and a decrease in sexual desire.
- Chronic renal or hepatic insufficiency.
- Diabetic nephropathy, anuria, acidosis.
- Hypercalcemia and hyperkalemia.
- Addison’s disease.
- Some gynecological diseases, including an increase in mammary glands.
- The first trimester of pregnancy.
- Individual intolerance to spironolactone.
Admission of Aldactone 100 mg during pregnancy and breastfeeding
Data on any negative effect of the drug on the course of pregnancy and the formation of the fetus are absent.
Nevertheless, in the first third of pregnancy, taking the drug is contraindicated , and at later times – is possible only if there are indications and with the consent of the doctor.
When breastfeeding Aldakton may be prescribed, but only after further consultation with the pediatrician.
Reception of the drug provokes the ingestion of the metabolite of pyrenolactone canrenone into breast milk.
Reviews about Aldactone 100mg
The high price of Aldactone, which is ten times higher than the cost of analogues, makes the drug treatment available not for all patients. Reviews of the medication confirm its therapeutic effect. However, most often the result obtained differs little from therapy with the use of cheaper verospilactone or spironolactone .
The rapid diuretic and antihypertensive effect of Aldactone intake is confirmed by about 85% of the reviews, but many patients also note the occurrence of adverse reactions.
Sometimes the reception of the drug is accompanied by a disruption in performance (drowsiness and dizziness), intestinal disorders (diarrhea), pain in the heart.
At the end of the article, you will find more feedback on the use of the drug.
The advantages of Aldacton include:
- high efficacy as a diuretic and antihypertensive drug ;
- rapidity of action (a noticeable diuretic effect usually occurs as early as the second day of taking the medicine);
- high absorption (the body processes about 90% of the active substance spironolactone);
- the minimum number of contraindications (only very serious diseases: hepatic and renal insufficiency, metabolic acidosis, anuria and some others);
- the possibility of taking the drug during pregnancy (except the first trimester) and breastfeeding;
- in some cases, Aldactone may be prescribed even to children.
The disadvantages of the drug can be attributed to its high price and the presence of side effects, the likelihood of occurrence of which increases with prolonged reception of Aldactone.